Author

Kourosh Hayatigolkhatmi

European Institute of OncologyORCID 0000-0002-9910-9756Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Elena CeccacciiD· 2 shared Roberta NoberiniiD· 2 shared Saverio MinucciiD· 2 shared Tiziana BonaldiiD· 2 shared Amir HosseiniiD· 1 shared Andrea MatteviiD· 1 shared Anna Aakula· 1 shared Antonello MaiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

Elena CeccacciORCID

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2 papers

Recent·Most cited

Cell cycle control of chromatin creates a therapeutic window for epigenetic therapy in tumors

Kourosh Hayatigolkhatmi, Riccardo Valzelli, Elena Ceccacci, Amir Hosseini, Oualid El Menna, Mauro Romanenghi, Isabella Pallavicini, Emanuel Soda, Ornella Ejlli, Emanuela Villa, Paolo Falvo, Pedro Vizán, Enrique Blanco, Sergi Aranda, Roxana Barkhordar, , Saverio Minucci

This paper shows that extending G1 phase in cancer cells creates a therapeutic window for epigenetic drugs, with LSD1 inhibition and CDK4/6 inhibition working synergistically to induce differentiation and improve survival in AML models.

bioRxiv · Sep 6, 2026 · PreprintCancer Biology

LSD1 serine 166 is a phosphorylation switch for chromatinlandscaping, gene activation, and tissue remodeling

Mukund Sharma, Anna Aakula, Oxana V. Denisova, Elena Ceccacci, Kourosh Hayatigolkhatmi, Jonatan Caroli, Reetta Nätkin, Marie-Catherine Laisne, Riikka Huhtaniemi, Sujan Ghimire, Johannes A. M. Merilahti, Roberta Noberini, Jesse Kamila, Otto Kauko, Andrea Mattevi, , Jukka K. Westermarck

This paper identifies S166 phosphorylation on LSD1 as a regulatory switch that controls gene activation, chromatin remodeling, and tumor microenvironment in non-hormonal cancer cells.

bioRxiv · May 14, 2025 · PreprintGenomics