SUMO Inhibition Plus CD40 Agonism Increases Anti-Tumor Immunogenicity Through Interferon Mediated Macrophage Activation
Kevin Li, Asimina S. Courelli, James Lee, Tatiana Hurtado de Mendoza, Alexei Martsinkovskiy, Evangeline Sari. Mose, Jay Patel, Isabella Ng, Siming Sun, M.D. Neranjan Tharuka, Hervé Tiriac, Yuan Chen, Andrew M. Lowy
This study shows that combining SUMO inhibition with CD40 agonism enhances anti-tumor immunogenicity in PDAC by improving macrophage function and T-cell infiltration, leading to improved survival in a mouse model.
bioRxiv · Dec 3, 2024 · PreprintCancer Biology