Author

Da-Wei Lin

Cold Spring Harbor LaboratoryORCID 0000-0002-6792-5433Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:diffusion model· 1 Assay:DNA methylation· 1 Organism:human· 1

Frequent Co-Authors

Alejandra DurániD· 1 shared Anirban SarkariD· 1 shared Jessica ZhouiD· 1 shared Jin ZhangiD· 1 shared Kaarina Hanington· 1 shared Kenneth ChangiD· 1 shared Ling ZhangiD· 1 shared Masayuki Nagai· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperGenomics

Alejandra DuránORCID

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2 papers

Recent·Most cited

Inferring Metabolic Objectives and Tradeoffs in Single Cells During Embryogenesis

Da-Wei Lin, Ling Zhang, Jin Zhang, Sriram Chandrasekaran

The paper infers metabolic objectives and tradeoffs in single cells during embryogenesis using integrated omics data and a novel framework combining metabolic modeling and machine learning.

Cell Systems · Jan 1, 2025Peer-reviewedSystems Biology

Designing DNA With Tunable Regulatory Activity Using Discrete Diffusion

Anirban Sarkar, Alejandra Durán, Yiyang Yu, Da-Wei Lin, Yijie Kang, Nirali Somia, Pablo Mantilla, Jessica Zhou, Masayuki Nagai, Ziqi Tang, Kaarina Hanington, Kenneth Chang, Peter K. Koo

This paper introduces D3, a generative model for designing regulatory DNA with tunable activity, showing improved performance over baselines in sequence generation and activity prediction.

bioRxiv · May 23, 2024 · PreprintGenomics