This paper introduces D3, a generative model for designing regulatory DNA with tunable activity, showing improved performance over baselines in sequence generation and activity prediction.

bioRxiv · May 23, 2024 · PreprintGenomics

Dicer promotes genome stability via the bromodomain transcriptional co-activator Brd4.

Michael J. Gutbrod, Benjamin Roche, Joshua I. Steinberg, Asad A. Lakhani, Kenneth Chang, Andrea J. Schorn, Robert A. Martienssen

The paper identifies Brd4 as a suppressor of genome instability in Dicer1-/- mouse embryonic stem cells, showing its role in coordinating transcription and replication of satellite repeats.

Nature Communications · Feb 22, 2022Peer-reviewedGenetics

The human Origin Recognition Complex is essential for pre-RC assembly, mitosis and maintenance of nuclear structure.

Hsiang-Chen Chou, Kuhulika Bhalla, Osama El Demerdesh, Olaf Klingbeil, Kaarina Hanington, Sergey S. Aganezov, Peter Andrews, Habeeb Alsudani, Kenneth Chang, Christopher R. Vakoc, Michael C. Schatz, William Richard McCombie, Bruce Stillman

This study shows ORC subunits and CDC6 are essential for pre-RC assembly, mitosis, and nuclear structure in human cells.

eLife · Feb 1, 2021Peer-reviewedMolecular Biology