Author

Kaarina Hanington

Cold Spring Harbor Laboratory

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Approach:diffusion model· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:sequence-to-function modeling· 1

Frequent Co-Authors

Kenneth ChangiD· 2 shared Alejandra DurániD· 1 shared Anirban SarkariD· 1 shared Bruce StillmaniD· 1 shared Christopher R. VakociD· 1 shared Da-Wei LiniD· 1 shared Habeeb AlsudaniiD· 1 shared Hsiang-Chen Chou· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersGenomics

Kenneth ChangORCID

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2 papers

Recent·Most cited

Designing DNA With Tunable Regulatory Activity Using Discrete Diffusion

Anirban Sarkar, Alejandra Durán, Yiyang Yu, Da-Wei Lin, Yijie Kang, Nirali Somia, Pablo Mantilla, Jessica Zhou, Masayuki Nagai, Ziqi Tang, Kaarina Hanington, Kenneth Chang, Peter K. Koo

This paper introduces D3, a generative model for designing regulatory DNA with tunable activity, showing improved performance over baselines in sequence generation and activity prediction.

bioRxiv · May 23, 2024 · PreprintGenomics

The human Origin Recognition Complex is essential for pre-RC assembly, mitosis and maintenance of nuclear structure.

Hsiang-Chen Chou, Kuhulika Bhalla, Osama El Demerdesh, Olaf Klingbeil, Kaarina Hanington, Sergey S. Aganezov, Peter Andrews, Habeeb Alsudani, Kenneth Chang, Christopher R. Vakoc, Michael C. Schatz, William Richard McCombie, Bruce Stillman

This study shows ORC subunits and CDC6 are essential for pre-RC assembly, mitosis, and nuclear structure in human cells.

eLife · Feb 1, 2021Peer-reviewedMolecular Biology