APP-induced patterned neurodegeneration exacerbated by APOE4 in C. elegans
Wisath Sae-Lee, Luisa L. Scott, Lotti Brose, Aliyah J. Encarnacion, Ted Shi, Pragati Kore, Lashaun O. Oyibo, Congxi Ye, Susan K Rozmiarek, Jonathan T. Pierce-Shimomura
This study shows that C. elegans can model AD-related neurodegeneration, demonstrating that APOE4 exacerbates APP-induced cholinergic neurodegeneration.
G3 Genes Genomes Genetics · Jun 24, 2020Peer-reviewedNeuroscience