Jonathan T. Pierce-Shimomura

This study shows that reducing endogenous tau in C. elegans mitigates APOE4-induced behavioral and axonal defects, suggesting a role for tau in AD-related neurodegeneration patterns.

This study shows that targeting the VHL-HIF axis suppresses mortality and cellular damage caused by APOE4 and other stressors in C. elegans and mice.

This study investigates transgenerational effects of alcohol on intoxication sensitivity in C. elegans using different treatment paradigms and finds generation-specific resistance and hypersensitivity.

This study shows that C. elegans can model AD-related neurodegeneration, demonstrating that APOE4 exacerbates APP-induced cholinergic neurodegeneration.

This study shows that long-term neuronal activity in C. elegans URX sensory neurons leads to dendritic branch elaboration, independent of oxygen sensitivity.

The paper shows that egl-1, a BH3-only gene in C. elegans, is transcriptionally regulated by neuronal activity and kinases in adult sensory neurons without inducing apoptosis.

This study identifies ten HSA21 orthologs in C. elegans essential for neuromuscular behaviors, including three involved in acetylcholine release, providing insights into Down syndrome-related genes.