NeuroscienceG3 Genes Genomes GeneticsPeer-reviewed
APP-induced patterned neurodegeneration exacerbated by APOE4 in C. elegans
Wisath Sae-Lee, Luisa L. Scott, Lotti Brose…·Jonathan T. Pierce-Shimomura
This study shows that C. elegans can model AD-related neurodegeneration, demonstrating that APOE4 exacerbates APP-induced cholinergic neurodegeneration.
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