Overactive mitochondrial DNA replisome causes neonatal heart failure via ferroptosis
Juan C. Landoni, Tuomas Laalo, Steffi Goffart, Riikka Kivelä, Karlo Skube, Anni I. Nieminen, Sara A. Wickström, James Bruce Stewart, Anu Suomalainen
This study shows that overactive mitochondrial DNA replication causes neonatal heart failure through ferroptosis by disrupting cardiac maturation and oxidative metabolism.
bioRxiv · Apr 4, 2022 · PreprintMolecular Biology