Riikka Kivelä

This study shows that NAD+ precursor treatment improves cardiac function but worsens erythroid maturation in mitochondrial progeria, highlighting tissue-specific effects of NAD+ boosting.

This study examines how NR supplementation and HIIT affect skeletal muscle epigenetic aging, finding opposing effects on epigenetic age acceleration across different clocks.

The paper examines how mechanical loading affects endothelial and muscle cells, revealing shared and distinct molecular responses similar to those seen during exercise.

This study shows that inhibiting cholesterol biosynthesis in rhabdomyosarcoma cells induces ER stress, apoptosis, and cell cycle arrest, suggesting a new therapeutic strategy for this aggressive cancer.

This study investigates the role of GLE1 in cellular homeostasis and development, showing that its dysfunction leads to embryonic lethality and mid-adulthood death in mice, with defects in neural crest-derived tissues and stress responses.

This study shows that niacin replenishes NAD+ levels, improves mitochondrial function, and reduces cachexia in cancer models and patients.

This study shows that overactive mitochondrial DNA replication causes neonatal heart failure through ferroptosis by disrupting cardiac maturation and oxidative metabolism.

The paper identifies KPNB1 and MYL4 as novel risk genes for congenital heart disease through GWAS, eQTL analysis, and functional validation in patient-derived cardiomyocytes.

This study shows that cardiovascular disease risk factors alter the transcriptome of cardiac endothelial cells, promoting mesenchymal features and senescence, with SERPINH1/HSP47 as a potential therapeutic target.