Steffi Goffart

The paper presents a chromosome-level reference genome for the Saimaa ringed seal, identifies genomic features, and explores evolutionary relationships and adaptations.

The study shows the Y951N mutation in POLgamma impairs its ability to switch between DNA synthesis and degradation, causing mtDNA depletion without directly affecting polymerase or exonuclease activity.

The paper investigates mitonuclear incompatibilities in hybrid hares by generating cybrids and analyzing their cellular fitness and metabolic effects.

This paper presents a high-quality chromosome-level genome assembly for the mountain hare, contributing to the European Reference Genome Atlas initiative.

The paper analyzes mitochondrial tandem repeat variation in hares, finding species-specific differences and suggesting these repeats are selfish genetic elements rather than regulatory.

Mirin prevents mtDNA breakage and immune response in MGME1-deficient cells through MRE11-independent mechanisms involving TOP3A and mtDNA replication termination.

The paper presents a high-quality chromosome-level genome assembly of the brown hare, providing insights into chromosomal evolution and hybridization with the mountain hare.

This paper identifies c17orf80 as a mitochondrial membrane protein interacting with nucleoids but not essential for mtDNA maintenance or expression in human cells.

This study shows that overactive mitochondrial DNA replication causes neonatal heart failure through ferroptosis by disrupting cardiac maturation and oxidative metabolism.