Anu Suomalainen

This study shows GDF15 enhances NAD+ salvage and reduces immune response in mitochondrial disease by upregulating NMRK2 and modulating redox homeostasis.

This study shows that NAD+ precursor treatment improves cardiac function but worsens erythroid maturation in mitochondrial progeria, highlighting tissue-specific effects of NAD+ boosting.

This study shows that mitochondrial DNA replication defects in skeletal muscle alter methylation patterns of phospholipids, histones, and RNA, linking mitochondrial dysfunction to methylation remodeling in mitochondrial myopathy.

The paper measures NAD and glutathione levels in blood across health, disease, aging, and NAD-boosting treatment, finding age-independent normal distributions and disease-specific redox fingerprints.

This study shows that the m.3243A>G mutation increases cell-free mtDNA release, triggering pyroptosis and inflammation in MELAS models.

This study examines how nutrient environments affect MRPL44-deficient cardiomyocytes, revealing distinct metabolic responses in glucose vs. lipid-rich conditions that contribute to mitochondrial hypertrophic cardiomyopathy.

This study shows mitochondrial dysfunction in astrocytes disrupts primary ciliary homeostasis, linking mitochondrial stress to ciliary signaling and neurodegenerative disease mechanisms.

This study shows that overactive mitochondrial DNA replication causes neonatal heart failure through ferroptosis by disrupting cardiac maturation and oxidative metabolism.

This study shows that twnk-1 in C. elegans is not the mitochondrial DNA replicative helicase, but instead has alternative mitochondrial functions.