Author

Thomas E. Spratt

Pennsylvania State UniversityORCID 0000-0002-6805-3729Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Abbey RebokiD· 2 shared Anirban PauliD· 1 shared Darryl PappiniD· 1 shared Dongxiao SuniD· 1 shared Mariela C. TorresiD· 1 shared Paolo CifaniiD· 1 shared Shilpi PauliD· 1 shared Tony T. HuangiD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 18 mutual co-author links

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2 shared papersCell Biology

Abbey RebokORCID

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2 papers

Recent·Most cited

Cell BiologyProceedings of the National Academy of SciencesPeer-reviewedJul 1, 2024

Activity of DNA polymerase κ across the genome in human fibroblasts

Mariela C. Torres, Abbey Rebok, Dongxiao Sun, Thomas E. Spratt

The paper develops a method to map Pol κ activity across the genome in human fibroblasts and finds it is enriched in euchromatin, gene promoters, and early S-phase replicated DNA.

9 citations

humanwhole-genome sequencing

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Molecular BiologybioRxivPreprintOct 27, 2022

Translesion synthesis polymerase kappa is recruited to ribosomal DNA to maintain rRNA transcription

Shilpi Paul, Abbey Rebok, Paolo Cifani…·Thomas E. Spratt

The paper identifies POLK's role in maintaining rRNA transcription by acting on ribosomal DNA during DNA damage, revealing its interaction with nucleolar proteins and dependence on PCNA ubiquitination and PARP1.

3 citations

experimental assay

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