Anirban Paul

Neuronal and vascular genome-maintenance states organize opposing multicellular architectures in the aging brain

The paper maps DNA damage response states in aging mouse brains, revealing opposing neuronal and vascular spatial patterns linked to genome maintenance.

DNA polymerase kappa supports repair-associated DNA synthesis and genome maintenance in postmitotic neurons

This study identifies DNA polymerase kappa (POLK) as essential for DNA repair and genome maintenance in postmitotic neurons, showing its role in preventing neurodegeneration and aging-related stress.

Scale-Aware Compositional Inference Improves Reproducibility and Uncovers Convergent Aging Programs in Spatial Transcriptomics

This paper introduces a scale-aware framework for spatial differential expression that improves reproducibility and identifies convergent aging programs in aged mouse brains.

Brain-wide connectivity and novelty response of the dorsal endopiriform nucleus in mice

This study maps the connectivity and function of the dorsal endopiriform nucleus in mice, revealing its role in olfaction and response to novel stimuli through Oxtr-expressing neurons.

Specific and comprehensive genetic targeting reveals brain-wide distribution and synaptic input patterns of GABAergic axo-axonic interneurons

An altered cell-specific subcellular distribution of translesion synthesis DNA polymerase kappa (POLK) in aging neurons

This study shows that DNA polymerase kappa (POLK) shifts from the nucleus to the cytoplasm in aging neurons, correlating with increased DNA damage and stress granule accumulation.

Translesion synthesis polymerase kappa is recruited to ribosomal DNA to maintain rRNA transcription

The paper identifies POLK's role in maintaining rRNA transcription by acting on ribosomal DNA during DNA damage, revealing its interaction with nucleolar proteins and dependence on PCNA ubiquitination and PARP1.

Nf1 deletion results in depletion of the Lhx6 transcription factor and a specific loss of parvalbumin+ cortical interneurons

This study shows that Nf1 deletion causes loss of parvalbumin+ cortical interneurons and reduces Lhx6 expression, affecting their development.

Diversity of GABAergic interneurons and diversification of communication modules in cortical networks

The paper explores the diversity of GABAergic interneurons and proposes a framework for understanding their communication properties through transcriptional signatures.

Addressing the looming identity crisis in single cell RNA-seq

The paper introduces MetaNeighbor, a framework to assess cell type replicability across scRNA-seq datasets and identifies replicable neuronal subtypes with robust marker genes.

Transcriptional Architecture of Synaptic Communication Delineates Cortical GABAergic Neuron Identity

The paper identifies a transcriptional architecture that defines GABAergic neuron identity through combinatorial gene expression patterns.