Darryl Pappin

Identification and Validation of an inhibitor of the protein kinases PIM and DYRK

This study identifies and validates CSH-4044, a small-molecule inhibitor from fermented wheat germ extract, as a specific inhibitor of PIM and DYRK kinases with potential therapeutic applications.

Novel small-molecule inhibitors of the protein kinase DYRK: Potential Therapeutic candidates in cancer

This study identifies two selective DYRK1A inhibitors, FC-2 and FC-3, which show antitumor effects in glioblastoma models.

Translesion synthesis polymerase kappa is recruited to ribosomal DNA to maintain rRNA transcription

The paper identifies POLK's role in maintaining rRNA transcription by acting on ribosomal DNA during DNA damage, revealing its interaction with nucleolar proteins and dependence on PCNA ubiquitination and PARP1.