Author

David Hidalgo

Universidad Nacional Autónoma de MéxicoORCID 0000-0002-6809-9209Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2

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Research Focus:differential expression· 2 Organism:E. coli· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

José UtrillaiD· 2 shared Alejandro Aguilar-VeraiD· 1 shared Bernhard Ørn PalssoniD· 1 shared César A. Martínez-OrtiziD· 1 shared Daniela Ledezma-TejeidaiD· 1 shared José Arcadio Farías‐RicoiD· 1 shared José Ignacio JiméneziD· 1 shared Lizeth Soto-Avila· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 16 mutual co-author links

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2 shared papersSystems Biology

José UtrillaORCID

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2 papers

Recent·Most cited

Potential benefit of loss-of-function on bacterial fitness

David Hidalgo, Lizeth Soto-Avila, Alejandro Aguilar-Vera, Daniela Ledezma-Tejeida, José Arcadio Farías‐Rico, José Utrilla

This study investigates how gene loss affects bacterial fitness in E. coli by analyzing proteomic data and identifying gene categories with varying fitness impacts.

bioRxiv · Aug 18, 2026 · PreprintSystems Biology

Regulatory perturbations of ribosome allocation reshape the growth proteome with a trade-off in adaptation capacity

David Hidalgo, César A. Martínez-Ortiz, Bernhard Ørn Palsson, José Ignacio Jiménez, José Utrilla

The paper shows that reducing ribosomal RNA operons or mutating rpoB in E. coli increases growth rate but reduces hedging functions and adaptation capacity.

bioRxiv · Aug 1, 2021 · PreprintSystems Biology