José Ignacio Jiménez

This study identifies Pseudomonas putida JM37 as a bacterial chassis capable of efficiently metabolizing ethylene glycol and producing polyhydroxyalkanoates, with potential for biotechnological applications.

The paper creates and characterizes LH2 variants in PNSB to study energy transfer dynamics and their impact on light-harvesting efficiency and bacterial fitness.

This study shows that splitting the violacein production pathway between two E. coli subpopulations increases violacein production by 2.5 times compared to monoculture.

This paper engineers environmental bacteria to degrade PET plastic by enhancing PET bioavailability and secreting a high-activity hydrolase.

The paper shows that reducing ribosomal RNA operons or mutating rpoB in E. coli increases growth rate but reduces hedging functions and adaptation capacity.

This study investigates how growth rate and nutrient quality affect gene expression capacity in bacteria, showing that metabolism governs resource usage and that low growth in high-quality medium maximizes synthetic gene expression.

This paper introduces a method to reduce proteome allocation in E. coli through minimal genetic interventions, improving recombinant production yield.

The paper develops a mechanistic model of gene expression and resource allocation to design controllers that restore modularity in synthetic gene circuits by dynamically allocating ribosomes.

The paper demonstrates how dynamic allocation of orthogonal ribosomes reduces ribosome-mediated gene coupling in synthetic circuits.

The paper investigates how resource competition affects genetic circuits in E. coli and provides a model to mitigate unintended behaviors by tuning resource demand coefficients.