Arsen Arakelyan

The paper benchmarks 2,234 transcriptomic harmonization approaches on B-cell lymphoma data, finding ComBat excels in cross-batch prediction quality.

Across 7,174 multi-platform lymphoma transcriptomes, only surrogate variable analysis and feature-specific quantile normalization corrected batch effects while keeping subtype and normal B-cell differences; top-scoring MNN erased biomarker correlations.

The paper develops a non-tumorigenic cell line, LX-2, for intranasal delivery of oncolytic viruses to the brain, showing improved resistance to viral replication and safety in mice.

The paper analyzes telomere maintenance pathway activities in human tissues to identify gene-level and tissue-specific patterns of telomerase and ALT pathway activation.

The paper develops a computational framework to reconstruct telomere maintenance pathways and assess their activity using gene expression data and literature.