ImmunologyCellular & Molecular Biology LettersPeer-reviewed
Hypoxia Inducible Factor 1α-driven steroidogenesis impacts systemic hematopoiesis
Deepika Watts, Nicolas Eberz, Mangesh T. Jaykar…·Ben Wielockx
This study shows that chronic glucocorticoid exposure, via HIF1 deficiency in adrenocortical cells, promotes HSPC expansion and myeloid bias while impairing B-cell development through GR-dependent mechanisms.
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