Deepika Watts

This study shows that chronic glucocorticoid exposure, via HIF1 deficiency in adrenocortical cells, promotes HSPC expansion and myeloid bias while impairing B-cell development through GR-dependent mechanisms.

This study investigates how HIF1α regulates steroidogenesis under acute hypoxia using cell lines, ex vivo models, and mice, finding HIF1α-dependent miRNA regulation and translational control of steroidogenic enzymes.

This study shows that reduced endoglin in bone marrow endothelial cells causes vascular remodeling and hematopoietic changes, similar to those in hereditary hemorrhagic telangiectasia.

This study shows that PHD2-HIF2 pathway regulates epinephrine synthesis and release in mouse adrenal glands, linking hypoxia signaling to catecholamine production and systemic glucose levels.

This study shows HIF1α is crucial for steroid hormone production in adrenal cells, with its absence increasing steroid levels and overexpression reducing them, affecting systemic health.