Author

Mangesh T. Jaykar

Technische Universität Dresden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:development & morphogenesis· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Ben WielockxiD· 3 shared Deepika WattsiD· 3 shared Peter MirtschinkiD· 3 shared Ali El‐ArmoucheiD· 2 shared Anja Krüger· 2 shared Anupam N. SinhaiD· 2 shared Cagdas Ermis· 2 shared Martina RauneriD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersMolecular Biology

Ben WielockxORCID

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Author profile →

3 papers

Recent·Most cited

Hypoxia Inducible Factor 1α-driven steroidogenesis impacts systemic hematopoiesis

Deepika Watts, Nicolas Eberz, Mangesh T. Jaykar, Anupam N. Sinha, Cagdas Ermis, Johanna Tiebel, Ulrike Baschant, Martina Rauner, Tatyana Grinenko, Triantafyllos Chavakis, Peter Mirtschink, Ali El‐Armouche, Ben Wielockx

This study shows that chronic glucocorticoid exposure, via HIF1 deficiency in adrenocortical cells, promotes HSPC expansion and myeloid bias while impairing B-cell development through GR-dependent mechanisms.

Cellular & Molecular Biology Letters · Aug 25, 2025Peer-reviewedImmunology

HIF1α controls steroidogenesis under acute hypoxic stress

Stephen Ariyeloye, Deepika Watts, Mangesh T. Jaykar, Cagdas Ermis, Anja Krüger, Denise Kaden, Barbara Krystyna Stepien, Vasileia Ismini Alexaki, Mirko Peitzsch, Nicole Bechmann, Peter Mirtschink, Ali El‐Armouche, Ben Wielockx

This study investigates how HIF1α regulates steroidogenesis under acute hypoxia using cell lines, ex vivo models, and mice, finding HIF1α-dependent miRNA regulation and translational control of steroidogenic enzymes.

Cell Communication and Signaling · Feb 13, 2025Peer-reviewedMolecular Biology

Endoglin regulates the integrity of the bone marrow vasculature

Diego Rodriguez, Mangesh T. Jaykar, Deepika Watts, Anupam N. Sinha, Diana Gaete, Anja Krüger, Peter Mirtschink, Martina Rauner, Triantafyllos Chavakis, Helen M. Arthur, Ben Wielockx

This study shows that reduced endoglin in bone marrow endothelial cells causes vascular remodeling and hematopoietic changes, similar to those in hereditary hemorrhagic telangiectasia.

bioRxiv · Jul 24, 2024 · PreprintMolecular Biology