Ben Wielockx

This study identifies microbiota-specific serum IgG as a mediator of gut-joint immune-endothelial crosstalk in arthritis, showing its role in initiating autoimmunity through endothelial barrier impairment and microbial translocation.

This study shows ACOD1 deficiency in microglia enhances inflammatory responses by altering arginine metabolism, specifically increasing argininosuccinate synthesis while reducing polyamine synthesis, dependent on ACLY.

The paper identifies HIF-1's role in regulating adrenal steroidogenesis through direct transcriptional control and miRNA biogenesis, revealing hypoxia's impact on miRNA-processing genes.

This study shows that chronic glucocorticoid exposure, via HIF1 deficiency in adrenocortical cells, promotes HSPC expansion and myeloid bias while impairing B-cell development through GR-dependent mechanisms.

This study identifies AZIN2 as a regulator of adipocyte progenitor fate through polyamine metabolism, showing its protective role against obesity and metabolic dysfunction.

This study investigates how HIF1α regulates steroidogenesis under acute hypoxia using cell lines, ex vivo models, and mice, finding HIF1α-dependent miRNA regulation and translational control of steroidogenic enzymes.

This study shows that reduced endoglin in bone marrow endothelial cells causes vascular remodeling and hematopoietic changes, similar to those in hereditary hemorrhagic telangiectasia.

This study shows that PHD2-HIF2 pathway regulates epinephrine synthesis and release in mouse adrenal glands, linking hypoxia signaling to catecholamine production and systemic glucose levels.

This study shows HIF1α is crucial for steroid hormone production in adrenal cells, with its absence increasing steroid levels and overexpression reducing them, affecting systemic health.