Martina Rauner

Deploying cross-species bone marrow niches to elucidate human hematopoietic stem cell regulation in vivo

This study uses a cross-species bone marrow niche model to show that plasticity in the murine niche supports human HSC engraftment, highlighting its role in stem cell function.

Preclinical Efficacy of Tasquinimod in Myelodysplastic Neoplasms: Restoring Erythropoiesis and Mitigating Bone Loss

This study evaluates tasquinimod's efficacy in MDS by showing it reduces inflammation, improves erythropoiesis, and enhances bone health in a mouse model.

Hypoxia Inducible Factor 1α-driven steroidogenesis impacts systemic hematopoiesis

This study shows that chronic glucocorticoid exposure, via HIF1 deficiency in adrenocortical cells, promotes HSPC expansion and myeloid bias while impairing B-cell development through GR-dependent mechanisms.

TMPRSS6 cleaves KCNE1 and causes arrhythmias in iron overload disease

This study identifies TMPRSS6 cleavage of KCNE1 as a mechanism causing arrhythmias in iron overload disease using human iPSC-derived cardiomyocytes and computational models.

Endoglin regulates the integrity of the bone marrow vasculature

This study shows that reduced endoglin in bone marrow endothelial cells causes vascular remodeling and hematopoietic changes, similar to those in hereditary hemorrhagic telangiectasia.

Post-embryonic development and aging of the appendicular skeleton in Ambystoma mexicanum

This study examines the post-embryonic development and aging of the appendicular skeleton in axolotls, showing continuous ossification and cellular changes throughout life.