Author

Sam L. Clark

University of YorkORCID 0000-0002-6865-4452Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Organism:human· 1 Assay:multiome· 1

Frequent Co-Authors

Erik R. FarquhariD· 2 shared Peter G. StockleyiD· 2 shared Rebecca Chandler-BostockiD· 2 shared Reidun TwarockiD· 2 shared Abdullah M. SyediD· 1 shared Abid JavediD· 1 shared Amy BarkeriD· 1 shared Andrew J. P. ScottiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersMicrobiology

Erik R. FarquharORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Pandemic Coronavirus Genome Packaging Relies on Multiple Dispersed Packaging Signals

Taha Y. Taha, Nikesh Patel, Sam L. Clark, Julia Rosecrans, Abdullah M. Syed, Rebecca Chandler-Bostock, Erik R. Farquhar, Lekshmi B. G. Nair, Abid Javed, Jennifer A. Doudna, Peter G. Stockley, Mélanie Ott, Reidun Twarock

This study identifies multiple dispersed packaging signals in the SARS-CoV-2 genome that cooperate to direct RNA packaging into virions, revealing a dynamic mechanism for coronavirus genome assembly.

bioRxiv · Jun 19, 2026 · PreprintMicrobiology

RNA X-ray footprinting reveals the consequences of an in vivo acquired determinant of viral infectivity

Rebecca Chandler-Bostock, Richard J. Bingham, Sam L. Clark, Andrew J. P. Scott, Emma Wroblewski, Amy Barker, Simon J. White, Eric C. Dykeman, Carlos P. Mata, Jen Bohon, Erik R. Farquhar, Reidun Twarock, Peter G. Stockley

The paper uses X-ray footprinting to determine the secondary structures of bacteriophage MS2 RNA in different states, revealing packaging signals and the impact of the Maturation Protein on RNA conformation and capsid structure.

bioRxiv · Aug 10, 2021 · PreprintMolecular Biology