Reidun Twarock

Pandemic Coronavirus Genome Packaging Relies on Multiple Dispersed Packaging Signals

This study identifies multiple dispersed packaging signals in the SARS-CoV-2 genome that cooperate to direct RNA packaging into virions, revealing a dynamic mechanism for coronavirus genome assembly.

A geometric criterion links HIV-1 capsid topography to its biophysical properties and function

The paper introduces a geometric criterion to quantify deviations in HIV-1 capsid structure from idealized models and links these deviations to biophysical properties and function.

Dynamic assembly of pentamer-based protein nanotubes

This study demonstrates how a circularly permuted enzyme can assemble into various hollow structures using pentamers, guided by structural and geometrical principles.

RNA X-ray footprinting reveals the consequences of an in vivo acquired determinant of viral infectivity

The paper uses X-ray footprinting to determine the secondary structures of bacteriophage MS2 RNA in different states, revealing packaging signals and the impact of the Maturation Protein on RNA conformation and capsid structure.