RNA X-ray footprinting reveals the consequences of an in vivo acquired determinant of viral infectivity
Rebecca Chandler-Bostock, Richard J. Bingham, Sam L. Clark, Andrew J. P. Scott, Emma Wroblewski, Amy Barker, Simon J. White, Eric C. Dykeman, Carlos P. Mata, Jen Bohon, Erik R. Farquhar, Reidun Twarock, Peter G. Stockley
The paper uses X-ray footprinting to determine the secondary structures of bacteriophage MS2 RNA in different states, revealing packaging signals and the impact of the Maturation Protein on RNA conformation and capsid structure.
bioRxiv · Aug 10, 2021 · PreprintMolecular Biology