Development of an optimized, non-stem cell line for intranasal delivery of therapeutic cargo to the central nervous system
Ali El‐Ayoubi, Arsen Arakelyan, Moritz Klawitter, Luisa Merk, Siras Hakobyan, Irene González-Menéndez, Leticia Quintanilla de Fend, Per Sonne Holm, Wolfgang Mikulits, Matthias Georg Schwab, Lusine Danielyan, Ulrike Naumann
The paper develops a non-tumorigenic cell line, LX-2, for intranasal delivery of oncolytic viruses to the brain, showing improved resistance to viral replication and safety in mice.
Molecular Oncology · Dec 20, 2023Peer-reviewedMolecular Biology