Irene González-Menéndez

The paper evaluates ICI-sorafenib combination therapy in TNBC using multimodal imaging and ex vivo analyses, showing tumor growth suppression and TME remodeling.

This study shows that GATA2 deficiency leads to hematological issues through bone marrow failure and maladaptation, with leukemia arising from genomic instability and proliferation defects.

This study shows that SMG6-dependent NMD prevents dsRNA accumulation and immunogenicity in HCC by maintaining dsRNA homeostasis and suppressing MHC-I-presented peptides.

The paper develops a non-tumorigenic cell line, LX-2, for intranasal delivery of oncolytic viruses to the brain, showing improved resistance to viral replication and safety in mice.

This study uses simultaneous fPET/fMRI to show that optogenetic stimulation suppresses nigrostriatal pathway activity through presynaptic autoinhibition, revealing a dissociation between BOLD signal depression and neuronal inactivity.