Matthias Georg Schwab

Development of an optimized, non-stem cell line for intranasal delivery of therapeutic cargo to the central nervous system

The paper develops a non-tumorigenic cell line, LX-2, for intranasal delivery of oncolytic viruses to the brain, showing improved resistance to viral replication and safety in mice.

Higher transcriptome stability during aging in long-lived giant mole-rats compared to short-lived rats

This study compares transcriptome stability during aging between long-lived giant mole-rats and short-lived rats, finding greater stability in mole-rats.

Genetic variation in human drug-related genes

The paper analyzes genetic variation in 806 drug-related genes using 60,706 human exomes, finding that most variants are rare but many patients carry functional variants affecting drug efficacy and risk varies by ancestry.

Effects of Prenatal Stress on Structural Brain Development and Aging in Humans

This review summarizes how maternal stress and malnutrition during pregnancy affect structural brain aging and age-related brain disorders in humans.