The molecular landscape of polycystic kidneys is marked by common alterations in purine metabolism
Jean-Paul Decuypere, Daniel Borràs, Priyanka Joseph Koshy, Ludwig Missiaen, Steffen Fieuws, Nikky Corthout, Humbert DE SMEDT, Diethard R.L. Monbaliu, Jacques Pirenne, Tania Roskams, Bart Ghesquière, Bert Bammens, Abhishek Dinkarnath Garg, Djalila Mekahli, Rudi Vennekens
The paper identifies purine metabolism as a common altered pathway in ADPKD cysts and cell models, showing its modulation suppresses cyst formation in vitro.
bioRxiv · Aug 7, 2025 · PreprintMolecular Biology