Bart Ghesquière

This study validates Precision Cut Lung Slices (PCLS) as an ex vivo model for lung cancer research, showing comparable drug efficacy to in vivo models and potential to reduce animal testing.

Mechanical overload activates hypoxia-inducible factor 1-alpha (HIF1a) in tenocytes to drive tendinopathy independently of VEGFA-mediated vascular ingrowth, and tenocyte Hif1a deletion prevents overload-induced tendon degeneration in mice.

LipidQMap is an open-source tool for processing quantitative mass spectrometry imaging lipidomics data, enabling accurate and reproducible spatial lipid quantification across MSI platforms.

The paper identifies purine metabolism as a common altered pathway in ADPKD cysts and cell models, showing its modulation suppresses cyst formation in vitro.

This study identifies biallelic COX18 variants as a cause of autosomal recessive axonal CMT with peripheral neuropathy and potential central nervous system involvement.

This study integrates proteomics, transcriptomics, and metabolomics data from IEM patients to identify perturbed protein complexes and pathways, highlighting mitochondrial oxidative phosphorylation and histone acetylation dysregulation.

This study shows that slower mitochondrial development and lower metabolic activity in human cortical neurons compared to mice delay neuronal maturation, and stimulating mitochondria accelerates this process.

This study shows that AMPK is essential for maintaining energy levels during synaptic activation by regulating mitochondrial respiration and supporting synaptic plasticity and memory formation.