Hailey-Hailey disease models identify synergistic therapeutic effects of MEK and ROCK inhibition
Jessica Ayers, Arti Parihar, Afua Tiwaa, Akshata Aravind, Michael C Martin, Kuga Pence, Crystal J Tam, Nizhoni Sutter, Kristen Skruber, Mrinal K. Sarkar, Johann Eli Gudjonsson, Cory L. Simpson
This study uses human keratinocyte models of Hailey-Hailey disease to show that combined MEK and ROCK inhibition restores epidermal integrity, suggesting a therapeutic strategy for this genetic skin disorder.
bioRxiv · May 23, 2026 · PreprintCell Biology