Cory L. Simpson

The paper identifies a pre-fibrotic stage in scleroderma by analyzing spatial transcriptomic changes in clinically uninvolved skin, showing early loss of fibroblast niches and vascular reprogramming.

This study shows that E-cadherin mediates ER recruitment to cell-cell junctions, forming ER-PMCS and integrating mechanical and lipid homeostasis.

This study uses human keratinocyte models of Hailey-Hailey disease to show that combined MEK and ROCK inhibition restores epidermal integrity, suggesting a therapeutic strategy for this genetic skin disorder.

This study identifies TEX264 as a key driver of epidermal differentiation through reticulophagy, showing its dysregulation in Darier disease.

This study investigates how stress exacerbates metabolic and oxidative stress in heterozygous Darier disease, leading to disrupted intercellular adhesion and skin lesions.

This study shows ERK hyperactivation in keratinocytes causes impaired adhesion and drives Grover disease, supporting MEK inhibition as a potential therapy.