Mrinal K. Sarkar

This study identifies VISTA as a suppressor of UV-induced IFN-I responses in keratinocytes, reducing skin injury in mice and human cells.

This study shows that keratinocytes produce IFN-kappa constitutively to protect human skin against RNA and DNA viruses through distinct antiviral mechanisms.

This study shows that SPCA1 deficiency in keratinocytes disrupts actin dynamics and insulin signaling, leading to impaired migration and wound healing, and identifies potential therapeutic strategies.

This study uses human keratinocyte models of Hailey-Hailey disease to show that combined MEK and ROCK inhibition restores epidermal integrity, suggesting a therapeutic strategy for this genetic skin disorder.

This study shows KRT16 inhibits type I interferon signaling and innate immunity in skin diseases, providing new insights into inflammatory skin disorder mechanisms.

This study shows that BP-IgG autoantibodies induce a pro-inflammatory response in keratinocytes via MyD88-dependent signaling, contributing to BP pathology.

This study identifies TEX264 as a key driver of epidermal differentiation through reticulophagy, showing its dysregulation in Darier disease.

This study identifies VGLL3 as a key driver of preeclampsia by linking it to placental, vascular, and immune defects, showing its therapeutic potential through genetic and pharmacological inhibition.

This study creates a high-resolution single-cell atlas of healthy human skin, revealing region-specific transcriptional networks and their links to inflammatory diseases.

This study performs a GWAS meta-analysis of psoriasis, identifying 109 susceptibility loci, including 45 new ones, and highlights potential therapeutic targets and disease mechanisms.

This study conducts a multi-ancestry GWAS meta-analysis of 56,146 AD cases and 602,280 controls, identifying 101 genomic loci, 15 novel to AD or eczema, and linking them to AD pathophysiology through functional analyses.