The Taiwan Precision Medicine Initiative (TPMI) recruits a large cohort for genetic and electronic medical record studies to advance precision medicine.

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Genetic & Genomic MedicineYearbook of pediatric endocrinologyPeer-reviewedSep 8, 2023

Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications

Suzuki Ken, Konstantinos Hatzikotoulas, Lorraine Southam…·H. Janaka de Silva

This study identifies 1,289 genetic signals for type 2 diabetes in 2.5 million individuals, revealing distinct clusters linked to vascular complications and highlighting ancestry-specific genetic risk factors.

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Genetic & Genomic MedicineDiscovery Research Portal (University of Dundee)Peer-reviewedJan 1, 2022

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

Anubha Mahajan, Cassandra Nichole Spracklen, Weihua Zhang…·Mary Cushman

This study identifies 277 T2D loci using diverse populations and improves fine-mapping to assess causal genes and mechanisms, enhancing clinical translation.

20 citations

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GeneticsNaturePeer-reviewedMay 6, 2020

Identification of type 2 diabetes loci in 433,540 East Asian individuals

Cassandra Nichole Spracklen, Momoko Horikoshi, Young Jin Kim…·Kyong Soo Park

This paper identifies 56 new type 2 diabetes loci in 433,540 East Asian individuals through a meta-analysis of GWAS data.

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