Hsin‐Chou Yang

This study conducts a large-scale GWAS meta-analysis across East Asian populations, identifying 8,010 new associations and revealing shared and population-specific genetic architectures for 127 complex traits.

The paper develops population-specific polygenic risk scores for Han Chinese using genomic and electronic health record data, showing strong predictive performance for multiple diseases.

The Taiwan Precision Medicine Initiative (TPMI) recruits a large cohort for genetic and electronic medical record studies to advance precision medicine.

The paper evaluates the clinical impact of pharmacogenetic risk variants in a large Han Chinese cohort, finding that while most carry risk variants, the excess risk of adverse events is small and most patients do not experience adverse outcomes.

The paper analyzes 292 disease-relevant deleterious variants in 486,956 participants to assess their risk differences, finding most have minimal impact.

The paper subtypes SARS-CoV-2 variants and identifies SNVs associated with transmission differences across multiple genomic datasets.