Author

Lea F. Surrey

Children's Hospital of PhiladelphiaORCID 0000-0002-6944-2232Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Aime T. FrancoiD· 1 shared Amber R. IsazaiD· 1 shared Andrew J. BaueriD· 1 shared Anika R. Kakarla· 1 shared Bishwanath ChatterjeeiD· 1 shared Corinne Mary LinardiciD· 1 shared Deanne TayloriD· 1 shared Erin R. RudzinskiiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperGenetics

Aime T. FrancoORCID

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2 papers

Recent·Most cited

DNA methylation profiling reveals novel rhabdomyosarcoma subsets with distinct histologic, genetic and clinical properties

Wenyue Sun, Jorge Lopez-Nava, Jack F. Shern, Erin R. Rudzinski, Michael Arnold, Lea F. Surrey, Monisha Raju, Anika R. Kakarla, Bishwanath Chatterjee, Corinne Mary Linardic, Philip J. Lupo, Frederic G. Barr

The paper uses DNA methylation profiling to identify distinct subsets within rhabdomyosarcoma subtypes, revealing clinical and genetic differences among them.

medRxiv · Oct 22, 2026 · PreprintGenetic & Genomic Medicine

Fusion-oncogenes are associated with increased metastatic capacity and persistent disease in pediatric thyroid cancers

Aime T. Franco, Julio C. Ricarte-Filho, Amber R. Isaza, Zachary Jones, Neil K. Jain, Sogol Mostoufi‐Moab, Lea F. Surrey, Theodore Willis Laetsch, Marilyn M. Li, Jessica Clague DeHart, Erin Reichenberger, Deanne Taylor, Ken Kazahaya, N. Scott Adzick, Andrew J. Bauer

This study shows that genetic subtypes of pediatric thyroid cancer, particularly RET/NTRK fusions, are linked to worse clinical outcomes compared to RAS- or BRAF-mutant subtypes.

Journal of Clinical Oncology · Jan 11, 2022Peer-reviewedGenetics