Frederic G. Barr

The paper uses DNA methylation profiling to identify distinct subsets within rhabdomyosarcoma subtypes, revealing clinical and genetic differences among them.

This study identifies PAX3::FOXO1 and MYCN as cooperative regulators of MIR17HG expression in fusion-positive rhabdomyosarcoma and shows miR-17-92 is necessary for oncogenic activity.

This study evaluates NAPRT expression and epigenetic regulation in pediatric rhabdomyosarcoma as a potential biomarker for NAMPT inhibitor therapy.

This study investigates the role of Myc family proteins in FP-RMS, showing MYCN or MYC dominance in some cases and functional redundancy in others, with both contributing to oncogenic properties.

This study shows that varying levels of PAX3::FOXO1 protein affect cell state and epigenetic heterogeneity in rhabdomyosarcoma.

This study investigates the chromatin-binding properties of the oncogenic PAX3-FOXO1 fusion protein using pc-ChIP-seq, revealing its pioneer function at repressed chromatin in RMS cells.