Erin Renée Reichenberger

This study identifies KEAP1 mutations in thyroid cancer, showing they activate the NRF2 pathway, promote cell growth and migration, and reduce drug response.

The paper uses single-nuclei RNA sequencing to analyze pediatric thyroid cells, identifying seven major cell types and seven thyrocyte subclusters with distinct functions.

SWANS is a configurable scRNA-seq analysis pipeline that integrates multiple methods and generates interactive reports for data visualization and comparison.

This study shows that genetic subtypes of pediatric thyroid cancer, particularly RET/NTRK fusions, are linked to worse clinical outcomes compared to RAS- or BRAF-mutant subtypes.

Scedar is a Python package for scRNA-seq exploratory analysis, offering visualization, imputation, rare profile detection, and clustering on large datasets efficiently and without distribution assumptions.