Julio C. Ricarte‐Filho

KEAP1 mutations activate the NRF2 pathway to drive cell growth and migration, and attenuate drug response in thyroid cancer

This study identifies KEAP1 mutations in thyroid cancer, showing they activate the NRF2 pathway, promote cell growth and migration, and reduce drug response.

Single-cell analysis reveals the cellular and transcriptional diversity of thyrocytes in the normal pediatric thyroid

The paper uses single-nuclei RNA sequencing to analyze pediatric thyroid cells, identifying seven major cell types and seven thyrocyte subclusters with distinct functions.

SWANS: A highly configurable analysis pipeline for single-cell and single-nuclei RNA-sequencing data

SWANS is a configurable scRNA-seq analysis pipeline that integrates multiple methods and generates interactive reports for data visualization and comparison.

Fusion-oncogenes are associated with increased metastatic capacity and persistent disease in pediatric thyroid cancers

This study shows that genetic subtypes of pediatric thyroid cancer, particularly RET/NTRK fusions, are linked to worse clinical outcomes compared to RAS- or BRAF-mutant subtypes.