Author

Amber R. Isaza

Children's Hospital of PhiladelphiaORCID 0000-0003-0863-7500Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:whole-exome sequencing· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1

Frequent Co-Authors

Aime T. FrancoiD· 3 shared Andrew J. BaueriD· 3 shared Erin Renée ReichenbergeriD· 3 shared Julio C. Ricarte‐FilhoiD· 3 shared Kyle HinkleiD· 2 shared Nicholas E. BambachiD· 2 shared Christian Hernandez-Padilla· 1 shared Deanne TayloriD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersCancer Biology

Aime T. FrancoORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cancer BiologyFrontiers in OncologyPeer-reviewedJan 7, 2026

KEAP1 mutations activate the NRF2 pathway to drive cell growth and migration, and attenuate drug response in thyroid cancer

Nicholas E. Bambach, Julio C. Ricarte‐Filho, Erin Renée Reichenberger…·Aime T. Franco

This study identifies KEAP1 mutations in thyroid cancer, showing they activate the NRF2 pathway, promote cell growth and migration, and reduce drug response.

2 citations

humanwhole-exome sequencing

𝕏 PostBluesky

Cell BiologybioRxivPreprintNov 17, 2025

Single-cell analysis reveals the cellular and transcriptional diversity of thyrocytes in the normal pediatric thyroid

Erin Renée Reichenberger, Nicholas E. Bambach, Zachary Spangler…·Aime T. Franco

The paper uses single-nuclei RNA sequencing to analyze pediatric thyroid cells, identifying seven major cell types and seven thyrocyte subclusters with distinct functions.

DOI 10.1101/2025.11.17.687863

humanbulk RNA-seq

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GeneticsJournal of Clinical OncologyPeer-reviewedJan 11, 2022

Fusion-oncogenes are associated with increased metastatic capacity and persistent disease in pediatric thyroid cancers

Aime T. Franco, Julio C. Ricarte-Filho, Amber R. Isaza…·Andrew J. Bauer

This study shows that genetic subtypes of pediatric thyroid cancer, particularly RET/NTRK fusions, are linked to worse clinical outcomes compared to RAS- or BRAF-mutant subtypes.

103 citationstop 1%

humanwhole-exome sequencing

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