Cryo-EM Structure of AAA + ATPase Thorase Reveals Novel Helical Filament Formation
Mohammad Aasif Dar, Robert K. Louder, Marisol Cortés, Rong Chen, Qianqian Ma, Mayukh Chakrabarti, George K. E. Umanah, Ted M. Dawson, Valina Lynn Dawson
The paper determines the cryo-EM structure of Thorase filaments, showing how ATP binding drives filament formation and provides insights into its role in disassembling mTORC1 complexes.
Computational and Structural Biotechnology Journal · Jan 1, 2025Peer-reviewedBiochemistry