Carl Wu

DNAsight automates AFM image analysis of chromatin organization, revealing protein-specific structural signatures and nucleosome spacing distributions.

This study uses live-cell single-molecule tracking in yeast to analyze the dynamics of RNA polymerase machineries, revealing new insights into transcriptional processes and the role of the CTD in splicing.

The paper structures SRCAP and TIP60 chromatin remodelers to reveal distinct mechanisms of chromatin engagement despite shared subunits.

The paper studies the kinetic behavior of the GAGA transcription factor in live Drosophila cells, showing it stably binds chromatin for over 2 minutes, independent of chromatin remodelers.

The paper identifies that FACT binds partially unwrapped nucleosomes in transcribed genes and spreads along genes in a Chd1-dependent manner.

This study uses live-cell imaging in yeast to show how PIC components explore the nucleus and assemble at promoters, revealing spatio-temporal coordination in transcription initiation.

The paper uses single-molecule imaging to study chromatin remodelers in budding yeast, revealing their fast kinetics and ATP-dependent dissociation from chromatin.

The paper uses live-cell single particle imaging to show that RNA polymerase II and Kin28/Cdk7 kinase are required for H2A.Z eviction in yeast, linking it to transcription processes.