Ana López‐Varea

Signaling by RasG12V depends on EGFR activity in vivo

This study shows RasG12V mutants amplify EGFR signaling, accelerating ERK activation but requiring EGFR for full pathway activation, suggesting combined inhibition of Ras and EGFR could improve therapy for RasG12V tumors.

A function of Spalt proteins in heterochromatin organization and maintenance of genomic DNA integrity

This study investigates the role of Spalt proteins in Drosophila cells, showing their involvement in heterochromatin organization and genomic DNA integrity through chromatin accessibility changes, DNA damage, and transposable element misexpression.

A function of Spalt major as a sequence-specific DNA binding transcription factor mediates repression of knirps in the Drosophila wing imaginal disc

The paper identifies a conserved DNA sequence bound by Spalt major that mediates transcriptional repression of knirps in Drosophila wing imaginal discs.