Charles Girardot

The paper identifies directional motif pairs that determine TAD boundary compatibility in Drosophila, showing conservation from flies to mammals.

This study investigates the role of Spalt proteins in Drosophila cells, showing their involvement in heterochromatin organization and genomic DNA integrity through chromatin accessibility changes, DNA damage, and transposable element misexpression.

This study shows glycolysis regulates the segmentation clock period in mouse embryos through a glycolysis-FBP-Wnt signaling axis, with FBP entraining Wnt oscillations.

The paper uses stem cell differentiation to study developmental tempo scaling across mammals and finds that segmentation clock periods correlate with phylogeny and biochemical kinetics of HES7, but not metabolic rates.

The paper shows TADs form during zygotic genome activation in Drosophila embryos without CTCF, BEAF-32, or CP190, but these factors have locus-specific roles in boundary insulation.