José Félix de Celis

This study shows RasG12V mutants amplify EGFR signaling, accelerating ERK activation but requiring EGFR for full pathway activation, suggesting combined inhibition of Ras and EGFR could improve therapy for RasG12V tumors.

This study investigates the role of Spalt proteins in Drosophila cells, showing their involvement in heterochromatin organization and genomic DNA integrity through chromatin accessibility changes, DNA damage, and transposable element misexpression.

The paper identifies a conserved DNA sequence bound by Spalt major that mediates transcriptional repression of knirps in Drosophila wing imaginal discs.

The paper challenges findings from a previous study on compartment boundaries in insect wings, showing that clones do not consistently respect a proposed lineage boundary near vein 5 in Drosophila.