Rebecca R. Viales

The paper identifies directional motif pairs that determine TAD boundary compatibility in Drosophila, showing conservation from flies to mammals.

This study shows SPT5 regulates Pol II pausing and elongation differently in early and late Drosophila embryogenesis, affecting gene expression dynamics.

The paper shows that Ldb1 (Chip) is a cofactor of Zelda that bridges to CBP to regulate gene expression during zygotic genome activation in Drosophila.

This study investigates the role of Spalt proteins in Drosophila cells, showing their involvement in heterochromatin organization and genomic DNA integrity through chromatin accessibility changes, DNA damage, and transposable element misexpression.

The paper identifies genetic variants affecting TF binding during Drosophila embryogenesis and uses a CNN to predict functional variants.

The paper shows TADs form during zygotic genome activation in Drosophila embryos without CTCF, BEAF-32, or CP190, but these factors have locus-specific roles in boundary insulation.

The paper identifies new enhancer-promoter interactions gained during tissue differentiation in Drosophila embryos, showing that E/P proximity correlates with activation during terminal differentiation.

The paper quantifies how cis-acting genetic variation affects chromatin accessibility, histone modifications, and gene expression in Drosophila embryos, finding that much of this variation does not propagate to gene expression.