Frances Mary Ashcroft

Hyperglycaemia reversibly disrupts circadian behaviour in mice

This study shows that hyperglycaemia reversibly disrupts circadian behaviour in mice by reducing rhythm amplitude and altering phase, with effects reversed upon normoglycaemia restoration.

Single-Cell Multimodal Profiling Reveals Maternal Diabetes-Nkx2-5 Interaction in Congenital Heart Disease in a Genetic Model Recapitulating Human Embryopathies

The paper shows that maternal diabetes and Nkx2-5 haploinsufficiency together cause severe cardiac defects in mice, with single-cell multiomic data revealing transcriptional and chromatin changes.

KATP channel mutation disrupts hippocampal network activity and nocturnal γ shifts

This study shows that KATP channel mutations in PV-interneurons disrupt gamma oscillations and cognitive function in DEND syndrome.