Jack J. J. J. Miller

The paper shows that maternal diabetes and Nkx2-5 haploinsufficiency together cause severe cardiac defects in mice, with single-cell multiomic data revealing transcriptional and chromatin changes.

In db/db mice, six weeks of AZD1656 improved diastolic function, cardiac metabolism and infarct size, with increased Treg infiltration and less fibrosis, without glycaemic change.

This paper introduces engineered magneto-sensitive fluorescent proteins that enable quantum sensing in living cells through optically detected magnetic resonance.

This study shows chronic kidney disease causes systemic metabolic failure across multiple organs, impairing cardiac function and stress resilience by depleting bioenergetic reserves.

This paper evaluates the effects of ninerafaxstat on cardiac energetics and function in patients with cardio-metabolic syndromes using hyperpolarized MR and metabolomics.

This study identifies maternal iron deficiency as an environmental teratogen causing congenital heart disease in mice, with potential implications for human health.