This study shows adult Drosophila muscles can fully remodel damaged myofibrils, with filamin mechanosignaling playing a critical role in repair, and identifies a progressive deterioration during aging.

bioRxiv · Sep 15, 2026 · PreprintCell Biology

Assessing the Replicability of Scientific Claims in Drosophila Immunity Through an Analysis of 400 Publications

Hannah E. Westlake, Fabrice P. A. David, Yao Tian, Kenan Krakovic, Prince Kumar Sah, Nathan Klotz, Asya Dolgikh, Liza Juravlev, Thomas Esmangart de Bournonville, Alexia Carboni, Claudia Melcarne, Tisheng Shan, Yang Wang, Yizhu Mu, Akshata Kotwal, , Bruno Lemaître

The paper assesses the replicability of claims in Drosophila immunity research by analyzing 400 publications and identifying contradictory evidence.

bioRxiv · Jul 7, 2025 · PreprintGenetics

A retrospective analysis of 400 publications reveals patterns of irreplicability across an entire life sciences research field

Joseph C. Lemaitre, Désirée Popelka, Blandine Ribotta, Hannah E. Westlake, Sveta Chakrabarti, Xiaoxue Li, Mark A. Hanson, Haobo Jiang, Francesca Di Cara, Estee Kurant, Fabrice P. A. David, Bruno Lemaître

This study retrospectively analyzed 400 Drosophila immunity papers to assess replicability, finding 61% of claims were verified, 7% challenged, and 24% unchallenged, with irreplicability linked to author experience and field trends.

bioRxiv · Jul 7, 2025 · PreprintScientific Communication & Education

Phage-displayed synthetic library and screening platform for nanobody discovery

Baolong Xia, Ah‐Ram Kim, Feimei Liu, Myeonghoon Han, Emily Stoneburner, Stephanie Makdissi, Francesca Di Cara, Stephanie Elizabeth Mohr, Aaron M. Ring, Norbert Perrimon

This study introduces a phage-displayed synthetic library for nanobody discovery and validates it by screening against Drosophila secreted proteins, demonstrating its utility for immunological applications.

bioRxiv · Dec 20, 2024Biochemistry